5 Airlines operate direct daily flights from the US, and a few thru Mexico City.
Panama operates as a hub for several airlines, getting from there to many places in the Americas like Costa Rica, Cuba, and South America is easy, if you want to make it a much longer trip, though there's plenty to do in Panama!
We have arranged a discount thru Continental and Copa. The discount can be significant from the fares available elsewhere, so worth taking a look. More details here!
Fares on offer vary widely depending on when you buy it, and sales are common. From LA and NY expect around $500-$700. From Miami, Atlanta and Houston $300-$500.
It's usually a good deal to use frequent-flyer miles if you can get them available, as most airlines only debit 30,000-35,000 miles from anywhere in the US.